Thyroglobulin Antibody MBS438052 from MyBioSource.com

Product Specs
ItemThyroglobulin Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS438052
Quantity0.1 mg
ApplicationsELISA (EIA), Flow Cytometry (FC/FACS), Western Blot (WB) Immunohistology (IH)
Conjugate/TagUnconjugated
ReactivityHuman, Mouse, Rat
TargetThyroglobulin
IsotypeIgG1 kappa
Molecular Weight660kDa (Dimeric Form)
Clone6E 1
HostMouse
ImmunogenThyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms
NCBI Full Gene Namethyroglobulin
NCBI Gene AliasesAITD3, TGN
ClonalityMonoclonal